Details

Autor(en) / Beteiligte

• Hu, Jia Ming
• Qian, Mei Zhen
• Tanigawa, Hisashi
• Song, Xue Mei
• Roe, Anna Wang

Titel

Focal Electrical Stimulation of Cortical Functional Networks

Ist Teil von

• Cerebral cortex (New York, N.Y. 1991), 2020-09, Vol.30 (10), p.5532-5543

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2020

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Traditional electrical stimulation of brain tissue typically affects relatively large volumes of tissue spanning multiple millimeters. This low spatial resolution stimulation results in nonspecific functional effects. In addition, a primary shortcoming of these designs was the failure to take advantage of inherent functional organization in the cerebral cortex. Here, we describe a new method to electrically stimulate the brain which achieves selective targeting of single feature-specific domains in visual cortex. We provide evidence that this paradigm achieves mesoscale, functional network-specificity, and intensity dependence in a way that mimics visual stimulation. Application of this approach to known feature domains (such as color, orientation, motion, and depth) in visual cortex may lead to important functional improvements in the specificity and sophistication of brain stimulation methods and has implications for visual cortical prosthetic design.