Details

Autor(en) / Beteiligte

• Cestonaro, Larissa V.
• Garcia, Solange Cristina
• Nascimento, Sabrina
• Gauer, Bruna
• Sauer, Elisa
• Göethel, Gabriela
• Peruzzi, Caroline
• Nardi, Jessica
• Fão, Nuryan
• Piton, Yasmin
• Braga, Wesley
• Rocha, Rafael
• Saint’Pierre, Tatiana
• Gioda, Adriana
• Arbo, Marcelo Dutra

Titel

Biochemical, hematological and immunological parameters and relationship with occupational exposure to pesticides and metals

Ist Teil von

• Environmental science and pollution research international, 2020-08, Vol.27 (23), p.29291-29302

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This study aimed to evaluate biomarkers of exposure to cholinesterase inhibitors insecticides (AChE and BuChE activities) and metals (As, Cd, Cr, Mn, Ni, and Pb blood levels) and their associations with biochemical, hematological, and immunological parameters in farmers from Southern Brazil. One hundred and sixteen individuals were divided into two groups: 62 farmers (exposed group) and 54 subjects non-occupationally exposed (NOE) to agrochemicals. Erythrocyte (AChE) and serum (BuChE) cholinesterases activities were significantly reduced as well as blood Cd and Pb levels were increased in farmers when compared to NOE group ( p  < 0.05). Farmers presented increased glucose and urea levels compared to NOE group, which were inversely associated with AChE and positively correlated with Cd ( p  < 0.05), respectively. In addition, Cd was inversely associated with the hematological cells counts, which were significantly reduced in farmers ( p  < 0.05). C3 complement was higher in farmers and was positively associated with blood Pb ( p  < 0.05). Surface protein expression analysis revealed a downregulation of LFA-1 and ICAM-1 in farmers. Inverse associations were found between LFA-1 and blood As, Cr, and Ni levels ( p  < 0.05). Taken together, our results pointed to a relationship between agrochemicals and metals exposure and biochemical, hematological, and immunological disorders that can lead to several chronic conditions.