Details

Autor(en) / Beteiligte

• Kosmas, Konstantinos
• Mitropoulou, Georgia
• Stamoulas, Marios
• Marouga, Anna

Titel

Expression of cyclooxygenase‐2 in imprint smears of endometrial carcinoma

Ist Teil von

• Diagnostic cytopathology, 2020-11, Vol.48 (11), p.1086-1092

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2020

Quelle

Wiley Online Library Journals【Remote access available】

Beschreibungen/Notizen

• Background Worldwide, endometrial carcinoma is one of the most frequently diagnosed cancers among women and a considerable cause of death. The aims of this study were to determine the expression of cyclooxygenase‐2 (COX‐2) in endometrial adenocarcinoma in imprint smears as an alternative technique and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. Methods One hundred twenty‐six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29‐month period. The cytologic imprint smears were obtained by touching the cut surface of cancer tissues and the expression of COX‐2 was assessed by immunocytochemistry. Results The positive expression of COX‐2 in malignant cells, was accompanied by morphologic features of more aggressiveness (pathogenetic type II, advanced clinical stage, mainly high grade, deep myometrial involvement >1/2) tumors and the affected from the disease lymph nodes cases showed higher positivity (41.2%) than the non‐affected (13.4%). Conclusion Immunocytochemical findings from COX‐2 stain in cancer cells could be a predictor of prognosis in most cases in endometrial cytology with imprint smears. Furthermore, positive expression of COX‐2 in cancer cells was related to morphologic features of more aggressiveness tumors.