Details

Autor(en) / Beteiligte

• C.B.B. Veiby, Nina
• Simeunovic, Aida
• Heier, Martin
• Brunborg, Cathrine
• Saddique, Naila
• Moe, Morten C.
• Dahl‐Jørgensen, Knut
• Margeirsdottir, Hanna D.
• Petrovski, Goran

Titel

Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy

Ist Teil von

• Acta ophthalmologica (Oxford, England), 2020-12, Vol.98 (8), p.800-807

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose To clarify how early in the development of diabetic retinopathy (DR) can oxygen (O2) saturation changes be detected. Methods Retinal oximetry was performed in a cross‐sectional study, involving 14‐ to 30‐year‐old individuals: 185 with type 1 diabetes (T1D) and 94 controls. The subjects were divided into four groups according to the grade of DR. One‐way ANOVA and post hoc tests were used to test for differences in the mean O2 saturations between the groups. Results Fifty‐eight (31 %) of the T1D patients had nonproliferative DR. There was no significant difference in O2 saturations between controls and T1D patients with no DR. Arteriolar and venular O2 saturations in T1D patients were significantly higher in moderate/severe DR than in no DR (p = 0.009 and p > 0.001), while venular O2 saturation was significantly higher in mild DR than in no DR (p = 0.013). Conclusion Increase in venular O2 saturation could not be detected before mild retinopathy had developed, and the retinal O2 saturation increase was measurable on the venular side first. Our results suggest that the increase in O2 saturation is likely a consequence of DR.