Details

Autor(en) / Beteiligte

• Murphy, Kevin R.
• Chipps, Bradley
• Beuther, David A.
• Wise, Robert A.
• McCann, William
• Eudicone, James M.
• Harding, Gale
• Coyne, Karin S.
• Zeiger, Robert S.
• Mohammad, Acklema
• Cherry, Adam T.
• Fein, Alan
• Allison Ramsey
• Michaud, Amanda L.
• Palmer, Amy
• Kim, Andrew S.
• Smith, Andrew M.
• White, Andrew A.
• Ricci, Anthony R.
• Modena, Brian D.
• Stone, Brian
• Krajicek, Bryan
• Kraft, Cara
• Hopkins, Carly
• Natalie, Chitra R.
• Anderson, Christine
• Czajkowski, Christine
• Arce, Daisy
• Hamlin, Danuel
• Pham, David
• Liao, Da-Wei
• Simmons, Deborah
• Johnson, Derek K.
• Jhaveri, Devi K.
• Kerwin, Edward
• Schuman, Edward
• Sher, Ellen R.
• Bleecker, Eugene
• Rakowski, Ewa
• Ida Hsu, Florence
• Averill, Francis J.
• Head, G. Gilbert
• Nasir, Hassan
• Barjaktarevic, Igor
• Cook, J. Paul
• Pearl, James E.
• Bellak, Jason M.
• Rehm, Jeffrey
• Trevor, Jennifer
• Hanson, Jill
• Blessing-Moore, Joann
• Gedell, John
• Southard, John G.
• Chancellor, Jon Eric
• Ilowite, Jonathan
• Romeo, Jonathan R.
• Manuel Mercado, Jorge
• Dominic Fisher, Joseph
• Greiwe, Justin
• Nadeau, Kari
• Shenoy, Kartik V.
• Stefanowicz, Leslie A.
• Humes, Lindsay D.
• Perez, Mario F.
• White, Martha V.
• Sikora, Maxcie M.
• Lee Morganroth, Melvin
• Smith, Mitchell
• Farooqui, Nabeel
• James Lesch, Nathan
• Jain, Neal
• Parikh, Neil
• Hartog, Nicholas L.
• Luthin, Patricia L.
• Stewart, Patricia H.
• Schochet, Peter
• Patel, Pulin P.
• Chinthrajah, R. Sharon
• Sidhu, Rabinder
• Ayinla, Raji M.
• Brown, Randall
• Wachs, Richard A.
• Balkissoon, Ronald C.
• Duplantier, Rory L.
• Puente, Rosalba E.
• Settipane, Russell
• Mustafa, S. Shahzad
• Surani, Salim
• Abdul Jawad, Sami
• Adams, Sandra G.
• Villegas, Sarah
• Bains, Sonia N.
• Kelsen, Steven G.
• Wise, Steven L.
• Smith, Susan M.
• Kelbel, Theodore E.
• Miller, Thomas P.
• Jain, Vipin
• Soler, Xavier
• Mattar, Ziad R.

Titel

Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure

Ist Teil von

• The journal of allergy and clinical immunology in practice (Cambridge, MA), 2020-07, Vol.8 (7), p.2263-2274.e5

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Asthma exacerbation risk increases with worsening asthma control. Prevailing numerical control tools evaluate only current symptom impairment despite the importance of also assessing risk based on exacerbation history. An easy-to-use questionnaire addressing impairment and risk domains of control is needed. To validate a composite asthma control tool that includes impairment and risk assessments (Asthma Impairment and Risk Questionnaire [AIRQ]). Four-hundred forty-two patients aged ≥12 years with physician-diagnosed asthma who were followed in specialty practices completed 15 impairment and risk questions with dichotomized yes/no responses. Patients spanned all Global Initiative for Asthma severities and were classified as well-controlled, not well-controlled, or very poorly controlled according to a standard of Asthma Control Test (ACT) score plus prior-year exacerbations. Logistic regression analyses identified questions with the greatest predictive validity to discriminate among patients and determine cut points for these 3 classifications. The final AIRQ comprises 10 equally weighted yes/no impairment and risk questions. The final 10-item models yielded receiver operating characteristic curves of 0.94 to identify well-controlled versus not well-/very poorly controlled and 0.93 to identify well-/not well-controlled versus very poorly controlled asthma, as reflected by the ACT plus prior-year exacerbations standard. Cut points of 0-1, 2-4, and 5-10 best represented well-, not well-, and very poorly controlled asthma. AIRQ is a rigorously validated composite measure designed to identify adults and adolescents with varying degrees of asthma control. Ongoing investigations will determine test-retest reliability, responsiveness to change, and predictive ability for future exacerbations.