Details

Autor(en) / Beteiligte

• Kadiri, Vincent Mauricio
• Bussi, Claudio
• Holle, Andrew W.
• Son, Kwanghyo
• Kwon, Hyunah
• Schütz, Gisela
• Gutierrez, Maximiliano G.
• Fischer, Peer

Titel

Biocompatible Magnetic Micro‐ and Nanodevices: Fabrication of FePt Nanopropellers and Cell Transfection

Ist Teil von

• Advanced materials (Weinheim), 2020-06, Vol.32 (25), p.e2001114-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The application of nanoparticles for drug or gene delivery promises benefits in the form of single‐cell‐specific therapeutic and diagnostic capabilities. Many methods of cell transfection rely on unspecific means to increase the transport of genetic material into cells. Targeted transport is in principle possible with magnetically propelled micromotors, which allow responsive nanoscale actuation and delivery. However, many commonly used magnetic materials (e.g., Ni and Co) are not biocompatible, possess weak magnetic remanence (Fe3O4), or cannot be implemented in nanofabrication schemes (NdFeB). Here, it is demonstrated that co‐depositing iron (Fe) and platinum (Pt) followed by one single annealing step, without the need for solution processing, yields ferromagnetic FePt nanomotors that are noncytotoxic, biocompatible, and possess a remanence and magnetization that rival those of permanent NdFeB micromagnets. Active cell targeting and magnetic transfection of lung carcinoma cells are demonstrated using gradient‐free rotating millitesla fields to drive the FePt nanopropellers. The carcinoma cells express enhanced green fluorescent protein after internalization and cell viability is unaffected by the presence of the FePt nanopropellers. The results establish FePt, prepared in the L10 phase, as a promising magnetic material for biomedical applications with superior magnetic performance, especially for micro‐ and nanodevices. Biocompatible hard nanomagnets that can easily be fabricated are shown to enable active gene delivery. Co‐depositing iron (Fe) and platinum (Pt) followed by an annealing step yields noncytotoxic ferromagnetic FePt nanopropellers that possess a remanence and magnetization that rival those of NdFeB micromagnets. This study describes the fabrication and material characterization, and shows that FePt is promising for microrobotics and biomedical applications.