Details

Autor(en) / Beteiligte

• Chen, Ying
• Li, Zi‐Hao
• Pan, Pei
• Hu, Jing‐Jing
• Cheng, Si‐Xue
• Zhang, Xian‐Zheng

Titel

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Ist Teil von

• Advanced materials (Weinheim), 2020-06, Vol.32 (24), p.e2001452-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Nanotheranostic agents (NTAs) that integrate diagnostic capabilities and therapeutic functions have great potential for personalized medicine, yet poor tumor specificity severely restricts further clinical applications of NTAs. Here, a pro‐NTA (precursor of nanotheranostic agent) activation strategy is reported for in situ NTA synthesis at tumor tissues to enhance the specificity of tumor therapy. This pro‐NTA, also called PBAM, is composed of an MIL‐100 (Fe)‐coated Prussian blue (PB) analogue (K2Mn[Fe(CN)6]) with negligible absorption in the near‐infrared region and spatial confinement of Mn2+ ions. In a mildly acidic tumor microenvironment (TME), PBAM can be specifically activated to synthesize the photothermal agent PB nanoparticles, with release of free Mn2+ ions due to the internal fast ion exchange, resulting in the “ON” state of both T1‐weighted magnetic resonance imaging and photoacoustic signals. In addition, the combined Mn2+‐mediated chemodynamic therapy in the TME and PB‐mediated photothermal therapy guarantee a more efficient therapeutic performance compared to monotherapy. In vivo data further show that the pro‐NTA activation strategy could selectively brighten solid tumors and detect invisible lymph node metastases with high specificity. A metal–organic framework hybrid is designed as a precursor of a nanotheranostic agent (pro‐NTA) to selectively synthesize an NTA with the release of Mn2+ ions in tumor tissues. This pro‐NTA activation strategy provides multimodal diagnosis and tumor treatment with high specificity.