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Breast cancer: Biology, biomarkers, and treatments
Ist Teil von
International immunopharmacology, 2020-07, Vol.84, p.106535-106535, Article 106535
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2020
Link zum Volltext
Quelle
ScienceDirect Journals (5 years ago - present)
Beschreibungen/Notizen
•BCSCs are the most critical cells leading to chemo and radio-resistance in tumor therapy.•Signaling pathways/metabolic components in BCSC could be targeted as a promising candidate treatment.•Nanoparticles combined with chemotherapy, are more efficient compared to the antibody-drug conjugates alone.•Biomarkers are regarded as proper prognostic and predictive factors in breast cancer.
During the past recent years, various therapies emerged in the era of breast cancer. Breast cancer is a heterogeneous disease in which genetic and environmental factors are involved. Breast cancer stem cells (BCSCs) are the main player in the aggressiveness of different tumors and also, these cells are the main challenge in cancer treatment. Moreover, the major obstacle to achieve an effective treatment is resistance to therapies. There are various types of treatment for breast cancer (BC) patients. Therefore, in this review, we present the current treatments, novel approaches such as antibody-drug conjugation systems (ADCs), nanoparticles (albumin-, metal-, lipid-, polymer-, micelle-based nanoparticles), and BCSCs-based therapies. Furthermore, prognostic and predictive biomarkers will be discussed also biomarkers that have been applied by some tests such as Oncotype DX, Mamm αPrint, and uPA/PAI-1 are regarded as suitable prognostic and predictive factors in breast cancer.