Science (American Association for the Advancement of Science), 2020-05, Vol.368 (6490), p.527-531
2020
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Details
- Autor(en) / Beteiligte
- Titel
- A noncanonical inhibitory circuit dampens behavioral sensitivity to light
- Ist Teil von
- Science (American Association for the Advancement of Science), 2020-05, Vol.368 (6490), p.527-531
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2020
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Retinal ganglion cells (RGCs) drive diverse, light-evoked behaviors that range from conscious visual perception to subconscious, non-image-forming behaviors. It is thought that RGCs primarily drive these functions through the release of the excitatory neurotransmitter glutamate. We identified a subset of melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) in mice that release the inhibitory neurotransmitter γ-aminobutyric acid (GABA) at non-image-forming brain targets. GABA release from ipRGCs dampened the sensitivity of both the pupillary light reflex and circadian photoentrainment, thereby shifting the dynamic range of these behaviors to higher light levels. Our results identify an inhibitory RGC population in the retina and provide a circuit-level mechanism that contributes to the relative insensitivity of non-image-forming behaviors at low light levels.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.aay3152Titel-ID: cdi_proquest_miscellaneous_2397676832
- Format
- –
- Schlagworte
- Animals, Brain, Circadian rhythms, Circuits, Dynamic range, Female, GABAergic Neurons - physiology, gamma-Aminobutyric Acid - metabolism, Glutamate Decarboxylase - metabolism, Light, Light levels, Luminous intensity, Male, Melanopsin, Mice, Mice, Mutant Strains, Neural Pathways - drug effects, Neural Pathways - physiology, Neuroimaging, Neurotransmitters, Photosensitivity, Reflex, Pupillary - physiology, Reflex, Pupillary - radiation effects, Retina, Retinal ganglion cells, Retinal Ganglion Cells - physiology, Retinal Ganglion Cells - radiation effects, Rod Opsins - metabolism, Sensitivity, Target recognition, Unconscious, Psychology, Visual perception, Visual Perception - physiology, Visual Perception - radiation effects, γ-Aminobutyric acid