Molecular immunology, 2020-06, Vol.122, p.124-131
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages
- Ist Teil von
- Molecular immunology, 2020-06, Vol.122, p.124-131
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2020
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- •TAOK1increases TLR4-induced cytokine production in macrophages;•Decreased systemic inflammatory responses in TAOK1 deficient mice;•TAOK1 interacts with TRAF6 and TPL2 and then promotes TLR4-triggered ERK1/2 activation. Thousand and one amino acid kinase 1 (TAOK1) is a member of Ste20-like kinases, but its function in regulating inflammatory responses remains largely unknown. In this study, we identify TAOK1 as a positive regulator of TLR4-triggered inflammatory responses in macrophages. TAOK1 increases LPS-induced production of pro-inflammatory cytokine such as IL-6, TNF-α and IL12p40 in macrophages. TAOK1 deficient mice showed decreased susceptibility to endotoxin shock, with less pro-inflammatory cytokine production than control mice. TAOK1 promotes LPS-induced activation of ERK1/2 by constitutively interacting with TRAF6 and TPL2. These finding unravel the important role of TAOK1 as a positive regulator of TLR4-induced inflammatory responses.