Details

Autor(en) / Beteiligte

• VanRaden, P.M.

Titel

Symposium review: How to implement genomic selection

Ist Teil von

• Journal of dairy science, 2020-06, Vol.103 (6), p.5291-5301

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Genomic selection was adopted very quickly in the 10 yr after first implementation, and breeders continue to find new uses for genomic testing. Breeding values with higher reliability earlier in life are estimated by combining DNA genotypes for many thousands of loci using existing identification, pedigree, and phenotype databases for millions of animals. Quality control for both new and previous data is greatly improved by comparing genomic and pedigree relationships to correct parent–progeny conflicts and discover many additional ancestors. Many quantitative trait loci and gene tests have been added to previous assays that used only evenly spaced, highly polymorphic markers. Imputation now combines genotypes from many assays of differing marker densities. Prediction models have gradually advanced from normal or Bayesian distributions within trait and breed to single-step, multitrait, or other more complex models, such as multibreed models that may be needed for crossbred prediction. Genomic selection was initially applied to males to predict progeny performance but is now widely applied to females or even embryos to predict their own later performance. The initial focus on additive merit has expanded to include mating programs, genomic inbreeding, and recessive alleles. Many producers now use DNA testing to decide which heifers should be inseminated with elite dairy, beef, or sex-sorted semen, which should be embryo donors or recipients, or which should be sold or kept for breeding. Because some of these decisions are expensive to delay, predictions are now provided weekly instead of every few months. Predictions from international genomic databases are often more accurate and cost-effective than those from within-country databases that were previously designed for progeny testing unless local breeds, conditions, or traits differ greatly from the larger database. Selection indexes include many new traits, often with lower heritability or requiring large initial investments to obtain phenotypes, which provide further incentive to cooperate internationally. The genomic prediction methods developed for dairy cattle are now applied widely to many animal, human, and plant populations and could be applied to many more.