Details

Autor(en) / Beteiligte

• Latos, Magdalena
• Nęcki, Mirosław
• Pawlak, Daria
• Urlik, Maciej
• Antończyk, Remigiusz
• Ochman, Marek
• Pokrontka, Marta Wajda
• Wojtasik, Monika
• Przybyłowski, Piotr
• Zembala, Marian
• Stącel, Tomasz

Titel

Outcome of Lung Transplantation as a Treatment of Patients With Chronic Obstructive Pulmonary Disease: A Single-Center Study

Ist Teil von

• Transplantation proceedings, 2020-09, Vol.52 (7), p.2118-2122

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. Lung transplantation (LTx) is often the only therapeutic option for patients with end-stage COPD. The aim of the study was to establish whether patients with end-stage COPD benefited from lung transplantation and assess the pulmonary function by the 6-Minute Walk Test (6MWT) and forced expiratory volume in 1 second (FEV1). A retrospective study was carried out in the group of 69 patients (40 recipients, 18 patients currently waiting, and 11 patients who died while waiting for a lung graft) diagnosed with end-stage COPD, referred to the Silesian Center for Heart Diseases’ Lung Transplant Ward, and qualified to be treated by means of lung transplantation between 2006 and 2018. The beginning of the observation for all 69 patients was a qualification date. Kaplan-Meier estimation determined that graft recipients noted 50% probability of survival at approximately 5.5 years, whereas patients from the other group had such parameters at about 1.4 years. The average results FEV1 obtained at qualification were 23.69% for single lung transplantation (SLT); and 22.06% for double lung transplantation (DLT). Average patient acquired 158.07m in the 6MWT. One year after procedure the average values of FEV1 were SLT, 55.83%; DLT, 79.54%; and 430.7 m in the 6MWT overall. Qualified patients who underwent lung transplantation lived longer than those who did not undergo such a procedure. We observed a difference in SLT and DLT recipients. •Lung transplantation extends the life of a patient with end-stage chronic obstructive pulmonary disease (COPD).•In addition to survival time, respiratory efficiency is also improved, as demonstrated by the results of functional tests.•Double lung transplantation is more beneficial for patients with end-stage COPD than single lung transplantation in terms of pulmonary function.