Details

Autor(en) / Beteiligte

• Faria, Luciana C.
• Andrade, Antônio Márcio F.
• Trant, Cyntia G. M. C.
• Lima, Agnaldo S.
• Machado, Pedro A. B.
• Porto, Rodrigo D.
• Andrade, Marcus Vinícius M.

Titel

Circulating levels of High‐mobility group box 1 protein and nucleosomes are associated with outcomes after liver transplant

Ist Teil von

• Clinical transplantation, 2020-07, Vol.34 (7), p.e13869-n/a

Ort / Verlag

Denmark

Erscheinungsjahr

2020

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background Liver transplantation (LT) can be associated with early complications, such as allograft dysfunction and acute kidney injury, which contribute significantly to morbidity and mortality. High‐mobility group box 1 protein (HMGB1) has been identified as mediator in ischemia‐reperfusion injury. Nucleosomes are complexes formed by DNA and histone proteins, and histones contribute to organs failure and death during sepsis. Methods HMGB1 and nucleosome plasma levels were measured, by enzyme‐linked immunosorbent assays, during LT and in the first 48 post‐operative hours in 22 LT patients. The association between HMGB1 and nucleosome levels and the complications and survival within 6 months after LT were investigated. Results We observed peak HMGB1 and nucleosome levels after graft reperfusion. HMGB1 and nucleosome levels were associated with the occurrence of acute kidney injury, early allograft dysfunction, and early survival after LT. Nucleosome levels after graft reperfusion were associated with the occurrence of systemic inflammatory response syndrome. Conclusions HMGB1 and nucleosome levels increased after liver reperfusion in human LT setting and were associated with early complications and survival. New studies are necessary to explore their role as early markers of hepatocellular injury in human LT and the risk of graft and organs dysfunction and death.