Details

Autor(en) / Beteiligte

• Qiao, Lixing
• Mo, Sisi
• Zhou, Yan
• Zhang, Yi
• Li, Bangbang
• Wu, Shun
• Lin, Lili
• Zhu, Lihua
• Zhao, Ruibin

Titel

Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage

Ist Teil von

• Genomics (San Diego, Calif.), 2020-07, Vol.112 (4), p.2875-2885

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Circular RNAs (circRNAs) are evolutionarily conserved and tissue-specific types of non-coding RNA and can serve as potential diagnostic biomarkers for disease. However, the clinical significance and levels of expression of circRNAs for whole blood samples of prematurely born infants afflicted by diseases such as periventricular white matter damage (PWMD) are largely unknown. Therefore, we sought to identify measures of expression of circRNAs in whole blood samples obtained from prematurely born infants afflicted by PWMD and comparatively in samples from prematurely born infants without PWMD. We found the expression levels of circRNAs which from premature with PWMD has changed. Further analysis suggests that these circRNAs have important roles in PWMD. This study can improve the understanding for the potential of the circRNAs to serve as biomarkers in PWMD. Moreover, these circRNAs may provide evidence for improving diagnosis and treatment for infants afflicted by PWMD, and merits continued research. •This is the first report describing perturbation of circular transcriptome in whole blood of premature infants with PWMD.•Five circRNAs were identified and validated as differentially expressed in prematurely born infants afflicted with PWMD.•ROC and bioinformatic analyses indicated that circRNAs could be potential biomarkers for diagnosis of PWMD。