Details

Autor(en) / Beteiligte

• Inoue, Hiroyuki
• Tanaka, Nobuaki
• Tanaka, Koji
• Ninomiya, Yuichi
• Hirao, Yuko
• Oka, Takafumi
• Okada, Masato
• Kitagaki, Ryo
• Takayasu, Kohtaro
• Koyama, Yasushi
• Okamura, Atsunori
• Iwakura, Katsuomi
• Fujii, Kenshi
• Sakata, Yasushi
• Inoue, Koichi

Titel

Burden and Long Firing of Premature Atrial Contraction Early After Catheter Ablation Predict Late Recurrence of Atrial Fibrillation

Ist Teil von

• Circulation Journal, 2020/05/25, Vol.84(6), pp.894-901

Ort / Verlag

Japan: The Japanese Circulation Society

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Background:Associations between characteristics of premature atrial contraction (PAC) 6 months after catheter ablation (CA) and later recurrence are not known. We investigated the effects of PAC characteristics on long-term outcomes of initially successful atrial fibrillation (AF) ablation.Methods and Results:In all, 378 patients (mean age 61 years, 21% female, 67% paroxysmal AF) who underwent initial radiofrequency CA for AF without recurrence up to 24-h Holter monitoring 6 months after the procedure were reviewed retrospectively. The calculated number of PAC/24 h and the length of the longest PAC run during Holter recording were analyzed. After 4.3±1.2 years (mean±SD) follow-up, 123 (32.5%) patients experienced late recurrence. Patients with recurrence had significantly more PAC/24 h (median [interquartile range] 110 [33–228] vs. 42 [16–210]; P<0.01) and a longer longest PAC run (5 [2–8] vs. 3 [1–5]; P<0.01) than those without. Receiver operating characteristic curve analysis indicated 58 PAC/24 h and a longest PAC run of 5 were optimal cut-off values for predicting recurrence. After adjusting for previously reported predictors of late recurrence, frequent PAC (≥58/24 h) and longest PAC run ≥5 were found to be independent predictors of late recurrence (hazard ratios [95% confidence intervals] 1.93 [1.24–3.02; P<0.01] and 1.81 [1.20–2.76; P<0.01], respectively).Conclusions:Six months after successful AF ablation, both frequent PAC and long PAC run are independent predictors of late recurrence.