Details

Autor(en) / Beteiligte

• Cao, Hao‐Qiang
• Liu, Hao‐Nan
• Liu, Zhe‐Yuan
• Qiao, Bao‐Kun
• Zhang, Fa‐Guang
• Ma, Jun‐An

Titel

Direct Enamido C(sp2)−H Diphosphorylation Enabled by a PCET‐Triggered Double Radical Relay: Access to gem‐Bisphosphonates

Ist Teil von

• Chemistry : a European journal, 2020-04, Vol.26 (24), p.5515-5521

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Herein we report a novel and straightforward protocol for the construction of valuable gem‐BPs by means of proton‐coupled electron‐transfer (PCET)‐triggered enamido C(sp2)−H diphosphorylation. This reaction represents a rare example of realizing the challenging double C−P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver‐mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET‐initiated radical relay process. C−P bond formation: By taking advantage of a PCET‐triggered radical relay process, a new general method to versatile valuable functionalized gem‐bisphosphonates is described (see scheme).