Doklady. Biochemistry and biophysics, 2019-11, Vol.489 (1), p.377-379
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes
- Ist Teil von
- Doklady. Biochemistry and biophysics, 2019-11, Vol.489 (1), p.377-379
- Ort / Verlag
- Moscow: Pleiades Publishing
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1607-6729eISSN: 1608-3091DOI: 10.1134/S1607672919060061Titel-ID: cdi_proquest_miscellaneous_2371857470
- Format
- –
- Schlagworte
- Animals, Biochemistry, Biological and Medical Physics, Biomedical and Life Sciences, Biophysics, Enzymatic activity, Genomes, Histones - chemistry, Histones - metabolism, Life Sciences, Molecular Biology, Nucleosomes, Nucleosomes - metabolism, Poly (ADP-Ribose) Polymerase-1 - metabolism, Poly(ADP-ribose) polymerase, Xenopus laevis