Details

Autor(en) / Beteiligte

• Somogyi, E.
• Hoornenborg, C.W.
• Bruggink, J.E.
• Nyakas, C.
• van Beek, A.P.
• van Dijk, G.

Titel

Ileal transposition: A non-restrictive bariatric surgical procedure that reduces body fat and increases ingestion-related energy expenditure

Ist Teil von

• Physiology & behavior, 2020-05, Vol.219, p.112844-112844, Article 112844

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Detailed methodology of ileal transposition (IT).•IT results in reduced body weight due to reduced body fat.•Increased ingestion-related energy expenditure after IT may contribute to long term weight loss. Ileal Transposition (IT) was developed as a model to study body weight reduction without the restrictive or malabsorptive aspects of other bariatric surgeries, but the exact mechanisms of the alterations in body weight after IT are not completely understood. To provide a detailed description of the surgical procedure of IT, and describe its effect on energy balance parameters. Adult male Lewis rats underwent either IT (IT+) or sham (IT-) surgery. Following surgery body weight and energy intake were monitored. After attaining weight stability (> 30 days), energy expenditure and its components were assessed using indirect calorimetry at a day of fasting, limited intake, and ad libitum intake. At the end of the study body composition analysis was performed. IT+ resulted in transiently reduced energy intake, increased ingestion-related energy expenditure (IEE) and decreased body and adipose tissue weight when compared to IT-. At weight stability, neither energy budget (i.e., energy intake - energy expenditure), nor energy efficiency was different in IT+ rats compared to IT-. Our data show that the primary cause of weight reduction following IT+ is a transient reduction in energy intake. If the increased IEE is related to a higher level of satiety, compensatory feeding to bridge body weight difference between IT+ and IT- rats is less likely to occur.