Details

Autor(en) / Beteiligte

• Okamura, Yasuyoshi
• Hinata, Nobuyuki
• Hoshiba, Taichi
• Nakatsuji, Tatsuya
• Ikeo, Naoko
• Furukawa, Junya
• Harada, Kenichi
• Nakano, Yuzo
• Fukumoto, Takumi
• Mukai, Toshiji
• Fujisawa, Masato

Titel

Development of bioabsorbable zinc–magnesium alloy wire and validation of its application to urinary tract surgeries

Ist Teil von

• World journal of urology, 2021, Vol.39 (1), p.201-208

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose Metallic medical devices are typically constructed from non-bioabsorbable metals that remains in the body and causes considerable complications. Particularly in the urinary tract, calculus, intractable infection, and misdiagnosis as calculus are often caused by non-bioabsorbable metals. Here, we developed a zinc–magnesium alloy as a new bioabsorbable metal and sought to evaluate the bioabsorbable behavior of zinc and zinc–magnesium alloy in a rat bladder implantation model. Methods We prepared zinc–magnesium alloy wires with various proportions of magnesium and investigated the strength, shape retention, formability, and absorbability of these novel materials. Then, we implanted zinc and zinc–magnesium alloy rings formed by the wires into rat bladder. Rats were euthanized at the end of the observation period, and the rings were removed for volume evaluation. Extracted bladder tissues were subjected to histological analysis. Results The strength of the zinc wire was enhanced by more than fourfold upon the addition of magnesium, without loss of ductility. Linear reduction of ring volume in urine was observed based on the concentration of magnesium within the ring. Nearly all rings were covered with a thin layer of calculus. Histological findings of the transected urinary bladder tissues did not differ among groups. Conclusions Zinc–magnesium alloy is a promising candidate for use as a bioabsorbable medical device in the urinary tract.