Details

Autor(en) / Beteiligte

• Shi, Shu
• Liu, Mingchen
• Xi, Jingyuan
• Liu, Hui
• Guan, Guiwen
• Shen, Congle
• Guo, Zhengyang
• Zhang, Ting
• Xu, Qiang
• Kudereti, Dilidaer
• Chen, Xiangmei
• Wang, Jie
• Lu, Fengmin

Titel

Sex-determining region Y box 4 (SOX4) suppresses Hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4α expression

Ist Teil von

• Antiviral research, 2020-04, Vol.176, p.104745-104745, Article 104745

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Hepatitis B virus (HBV) infection is still a health care crisis in the world, and a considerable number of chronic hepatitis B patients die of end-stage liver diseases, including liver cirrhosis and hepatocellular carcinoma. A previous study has reported that sex-determining region Y box 4 (SOX4) promotes HBV replication by binding to the AACAAAG motif in the viral genome. However, such SOX4 binding site was not found in the genome of the majority of HBV genotype strains. Further, we found that SOX4 inhibited rather than promoted the replication of most HBV strains. In line with this, HBV replication was significantly enhanced when the endogenous SOX4 was knocked down. Moreover, we demonstrated that the SOX4-induced suppression of HBV replication was mainly mediated by hepatocyte nuclear factor 4α (HNF4α). Taken together, our findings suggest that SOX4 plays an important antiviral role by inhibiting HNF4α expression in most HBV strains. •Only a few HBV strains of genotypes A and D contain the SOX4 binding site “AACAAAG”.•SOX4 inhibits the replication of most HBV strains.•SOX4 inhibits HBV replication by suppressing HNF4α expression.