Details

Autor(en) / Beteiligte

• Arcese, William
• Cerretti, Raffaella
• Sarmati, Loredana
• Cudillo, Laura
• De Angelis, Gottardo
• Mariotti, Benedetta
• Bruno, Antoine
• Mangione, Ilaria
• Rapanotti, Cristina
• Andreani, Marco
• De Fabritiis, Paolo
• Dentamaro, Teresa
• Cupelli, Luca
• Mengarelli, Andrea
• Marchesi, Francesco
• Tirindelli, Maria Cristina
• Annibali, Ombretta
• Tafuri, Agostino
• Ferrari, Antonella
• Cedrone, Michele
• Anaclerico, Barbara
• Adorno, Gaspare
• Miccichè, Silvia
• Andreoni, Massimo
• Picardi, Alessandra

Titel

Matched-Pair Analysis of Transplant from Haploidentical, Unmanipulated Bone Marrow Donor versus HLA Identical Sibling for Patients with Hematologic Malignancies

Ist Teil von

• Biology of blood and marrow transplantation, 2020-06, Vol.26 (6), p.1113-1118

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• •Comparable outcomes between HLA identical sibling and haploidentical transplants.•Similar incidence of advanced graft-versus-host disease with prophylaxis not including post-transplant cyclophosphamide (CTX).•Combined donor-recipient characteristics more important than HLA matching. A matched-pair analysis of transplant-related outcomes was carried out in 116 of 255 consecutive patients who received transplants from an HLA identical sibling (n = 58) or haploidentical related donor (n = 58). The 2 patient series were matched with 9 variables: period of transplant, patient and donor age, sex, diagnosis, disease phase, conditioning regimen, donor-recipient sex, and cytomegalovirus (CMV) status combinations. As graft-versus-host disease (GVHD) prophylaxis, all patients received the standard cyclosporine and methotrexate association with the addition of anti-thymocyte globulins, mycophenolate mofetil, and basiliximab in haploidentical, unmanipulated bone marrow recipients. Anti-infectious management, transfusion policy, and supportive care were identical for all patients. By comparing the 2 patient series, no statistically significant difference was observed for the cumulative incidence of advanced acute and extensive chronic GVHD, transplant-related mortality, and relapse. With a median follow-up of 3.5 years, the 5-year disease-free survival was 37% ± 6% and 36% ± 6% for HLA identical sibling and haploidentical recipients, respectively. The results of transplant from HLA identical siblings and haploidentical donors are comparable. Regardless of the HLA matching, other factors known to affect the transplant outcomes, such as donor-recipient age, sex, and CMV status combinations, might drive the search for the best donor.