Details

Autor(en) / Beteiligte

• García-Brito, Soleil
• Aldavert-Vera, Laura
• Huguet, Gemma
• Kádár, Elisabet
• Segura-Torres, Pilar

Titel

Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation

Ist Teil von

• Neurobiology of learning and memory, 2020-03, Vol.169, p.107188-107188, Article 107188

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• •SB-334867 impairs both spatial memory and visual discrimination in the MWM.•ICSS compensates for the detrimental effects of SB-334867 on both memory paradigms.•OX1R blockade partially negates the facilitating effect of ICSS on spatial memory.•OX1R blockade severely hinders ICSS facilitation of the discrimination task.•The orexinergic system’s involvement in ICSS facilitative effect is task-dependent. Intracranial self-stimulation (ICSS) of the medial forebrain bundle is an effective treatment to facilitate memory. Performance in both explicit and implicit memory tasks has been improved by ICSS, and this treatment has even been capable of recovering loss of memory function due to lesions or old age. Several neurochemical systems have been studied in regard to their role in ICSS effects on memory, however the possible involvement of the orexinergic system in this facilitation has yet to be explored. The present study aims to examine the relationship between the OX1R and the facilitative effects of ICSS on two different types of memory tasks, both carried out in the Morris Water Maze: spatial and visual discrimination. Results show that the OX1R blockade, by intraventricular administration of SB-334867, partially negates the facilitating effect of ICSS on spatial memory, whereas it hinders ICSS facilitation of the discrimination task. However, ICSS treatment was capable of compensating for the severe detrimental effects of OX1R blockade on both memory paradigms. These results suggest different levels of involvement of the orexinergic system in the facilitation of memory by ICSS, depending on the memory task.