Details

Autor(en) / Beteiligte

• Sykorova, A.
• Mocikova, H.
• Lukasova, M.
• Koren, J.
• Stepankova, P.
• Prochazka, V.
• Belada, D.
• Klaskova, K.
• Gaherova, L.
• Chroust, K.
• Buresova, L.
• Markova, J.

Titel

Outcome of elderly patients with classical Hodgkin’s lymphoma

Ist Teil von

• Leukemia research, 2020-03, Vol.90, p.106311-106311, Article 106311

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Risk factors for OS and PFS are lymphopenia<8 % and anthracycline-free chemotherapy.•CIRS > 3 is an independent risk factor for OS but not for PFS in elderly patients.•Importance of the careful comprehensive initial assessments before treatment.•Shorter 5-year PFS and 5-year OS in elderly pts when compared to younger adults. The optimal management of elderly patients (pts) with Hodgkin's lymphoma is not yet defined. The aims of the present study were: 1) to evaluate clinical and laboratory characteristics of elderly pts; 2) to indentify risk factors for unfavorable outcome. The outcome of 182 pts ≥ 60 years (y) was retrospectively analyzed (median age, 67y). Mixed cellularity histology was diagnosed in 49.5 %, advanced stage of disease was in 68.7 % pts, CIRS > 3 in 35.7 %, ECOG PS ≥ 2 in 22.9 % (60-69y) of pts. Chemotherapy (CMT) alone was used in 69.2 % and combination of CMT and radiotherapy in 26.9 % of pts. Anthracycline-based CMT received 83.5 % of pts. The median follow-up was 4.5y. The overall response/complete remission rate was 85.6/70.7 %. The median progression free survival (PFS) and overall survival (OS) were 10y and 11.3y, respectively. Estimated 5-y PFS and 5-y OS were 65.7 % (in contrast to 98.2 % in pts < 60y; p < 0.001) and 70.5 % (99.4 % in pts < 60y; p < 0.001). Overall 70 (38.5 %) elderly pts died. The independent risk factors for a shorter OS included CIRS > 3, lymphopenia < 8 % and anthracycline-free CMT, for a shorter PFS anthracycline-free CMT and lymphopenia < 8 %. CIRS > 3, lymphopenia < 8 % and anthracycline-free chemotherapy appear to be significant for unfavorable outcome.