Details

Autor(en) / Beteiligte

• Park, Sung‐Soo
• Lim, Ji‐Young
• Kim, Tae Woo
• Ko, Yoon Ho
• Jeon, Wan‐Jin
• Lee, So‐Young
• Lee, Jae‐Hoon
• Min, Chang‐Ki

Titel

Predictive impact of circulating microRNA‐193a‐5p on early relapse after autologous stem cell transplantation in patients with multiple myeloma

Ist Teil von

• British journal of haematology, 2020-05, Vol.189 (3), p.518-523

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary We explored prognostic roles of circulating microRNAs (miRs) in multiple myeloma (MM) treated with autologous stem cell transplantation (ASCT) following induction chemotherapy. In part I of the study (n = 40), we identified a decreasing dynamics of circulating miR‐193a‐5p expression from diagnosis to pre‐ASCT. In patients who experienced early relapse within one year post ASCT (n = 9) these patterns were distinctive compared to those without early relapse in a 1:2 matched cohort (n = 18). In part II (n = 90), multivariate analyses showed that the International Staging System score and miR‐193a‐5p expression before ASCT were independent prognostic factors. Conclusively, expression of circulating miR‐193a‐5p before ASCT could be a prognostic biomarker for transplant‐eligible MM.