Details

Autor(en) / Beteiligte

• Wang, Jiayao Y.
• Li, Jiaqi Q.
• Xiao, Yumei M.
• Fu, Bin
• Qin, Zhaohai H.

Titel

Triphenylphosphonium (TPP)‐Based Antioxidants: A New Perspective on Antioxidant Design

Ist Teil von

• ChemMedChem, 2020-03, Vol.15 (5), p.404-410

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Mitochondrial oxidative damage and dysfunction contribute to a wide range of human diseases. Considering the limitation of conventional antioxidants and that mitochondria are the main source of reactive oxygen species (ROS) which induce oxidative damage, mitochondria‐targeted antioxidants which can selectively block mitochondrial oxidative damage and prevent various types of cell death have been widely developed. As a lipophilic cation, triphenylphosphonium (TPP) has been commonly used in designing mitochondria‐targeted antioxidants. Conjugated with the TPP moiety, antioxidants can achieve more than 1000‐fold higher mitochondrial concentration depending on cell membrane potentials and mitochondrial membrane potentials. Herein we discuss the deficiencies of conventional antioxidants and the advantages of mitochondrial targeting, and review various types of TPP‐based mitochondria‐targeted antioxidants. These provide theoretical and background support for the design of new anti‐oxidant. Mitochondrial oxidative damage contributes to a wide range of human diseases. Conventional antioxidants usually fail to achieve satisfactory results, probably because these antioxidants have difficulty entering mitochondria. However, TPP‐based antioxidants can selectively and efficiently deliver antioxidants to mitochondria to block mitochondrial oxidative damage, which brings a new perspective to the design of antioxidant drugs.