Details

Autor(en) / Beteiligte

• Cole, Kristina A

Titel

Targeting ATRX Loss through Inhibition of the Cell-Cycle Checkpoint Mediator WEE1

Ist Teil von

• Cancer research (Chicago, Ill.), 2020-02, Vol.80 (3), p.375-376

Ort / Verlag

United States

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In this issue of , Liang and colleagues perform a genome-wide CRISPR-Cas9-negative loss-of-function screen and identify kinase as a therapeutic vulnerability in cells depleted of the chromatin remodeler gene. Because ATRX mutations are frequently mutated across a variety of pediatric and adult malignancies, this work may contribute to the preclinical rationale for a precision medicine trial of the WEE1 inhibitor AZD1775 (adavosertib) for patients whose tumors demonstrate ATRX loss. .