Details

Autor(en) / Beteiligte

• Moussiliou, A
• Turner, L
• Cottrell, G
• Doritchamou, J
• Gbédandé, K
• Fievet, N
• Luty, A J F
• Massougbodji, A
• Theander, T G
• Deloron, P
• Lavstsen, T
• Tuikue Ndam, N

Titel

Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants

Ist Teil von

• The Journal of infectious diseases, 2020-06, Vol.221 (12), p.2010-2017

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Plasmodium falciparum-infected erythrocytes bind to specific endothelial cell receptors via members of the PfEMP1 family exported onto the erythrocyte surface. These interactions are mediated by different types of cysteine-rich interdomain region (CIDR) domains found in the N-terminal region of all PfEMP1. CIDRα1 domains bind endothelial protein C receptor (EPCR), CIDRα2–6 domains bind CD36, whereas the receptor specificity of CIDRβ/γ/δ domains is unknown. Methods In this study, we investigated the level of immunoglobulin (Ig)G targeting the different types of PfEMP1 CIDR during the first year of life. We used plasma collected longitudinally from children of pregnant women who had been followed closely through pregnancy. Results Antibodies to CIDRα1 domains were more frequent in cord blood compared with antibodies to CIDRα2–6 domains. Higher IgG levels to EPCR-binding CIDRα1 variants positively correlated with the timing of first infections. Antibodies to all PfEMP1 types declined at similar rates to the point of disappearance over the first 6 months of life. At 12 months, children had acquired antibody to all types of CIDR domains, mostly in children with documented P falciparum infections. Conclusions These observations agree with the notion that the timing and phenotype of first P falciparum infections in life are influenced by the immune status of the mother. Analysis of the dynamics of anti-PfEMP1 IgG in a cohort of newborns in Benin showed acquisition of antibody to all types of CIDR domains at 12 months of age, with a significantly broader response in children with documented malaria infections.