Details

Autor(en) / Beteiligte

• Mejía-Vilet, Juan M.
• Martín-Nares, Eduardo
• Cano-Verduzco, Mayra L.
• Pérez-Arias, Abril A.
• Sedano-Montoya, Manuel A.
• Hinojosa-Azaola, Andrea

Titel

Validation of a renal risk score in a cohort of ANCA-associated vasculitis patients with severe kidney damage

Ist Teil von

• Clinical rheumatology, 2020-06, Vol.39 (6), p.1935-1943

Ort / Verlag

London: Springer London

Erscheinungsjahr

2020

Link zum Volltext

Quelle

SpringerLink

Beschreibungen/Notizen

• Objective To validate the renal risk score in a cohort of patients with advanced kidney damage. Methods A total of 72 patients with biopsy-proven ANCA glomerulonephritis with >12 months of follow-up were studied. The renal risk score was calculated and evaluated by survival analysis for time of renal survival. Cohort-specific clinical, histopathologic, and post-treatment factors associated with renal survival were determined by Cox regression analysis. Results Kidney biopsies were classified as focal, crescentic, mixed, and sclerotic classes in 6 (8%), 4 (6%), 25 (35%), and 37 (51%) patients, respectively. The 1-, 3-, and 5-year renal survival rates were 79%, 73%, and 68%, respectively. Patients were segregated by the risk score in low- (18%), medium- (47%), and high-risk (35%) groups. Patients in the low-risk group had 36-, 60-, and 84-month renal survival of 100%; those in the medium risk 85% (95% CI 72–92), 81% (95% CI 66–95), and 76% (95% CI 60–92), respectively; and those in the high risk 37% (95% CI 17–57), 26% (95% CI 7–45), and 18% (95% CI 1–36), respectively. Six (43%) of the 14 patients in the high-risk group recovered renal function after the initial episode, and 2 (14%) remained dialysis-free. Other parameters associated with renal survival included age, proteinuria, general symptoms, cellular crescents, glomerulosclerosis, tubulointerstitial lesions, best post-treatment eGFR, and renal relapses. Conclusions We validated the renal risk score as a prognostic tool in a cohort with predominantly mixed and sclerotic histologic categories. Since patients in the high-risk group still benefited from immunosuppressive therapy, this score should be used in conjunction with other predictive parameters to aid therapeutic decisions. Key Points • The ANCA renal risk score is validated in a cohort with advanced kidney damage. • Patients in the high-risk group still benefited from immunosuppressive therapy. • Parameters not included in the risk score are associated with renal survival and may be useful.