Details

Autor(en) / Beteiligte

• Killick, Sally
• Karakantza, Marina
• Hodge, Renate L.
• Hopkins, Valerie
• Deary, Alison J.
• Callum, Jeannie
• Lin, Yulia
• Wood, Erica M.
• Buckstein, Rena
• Wallis, Louise
• Rabbi, Taslima
• Serrano, Monica
• Williams, Rachel
• Watson, Lucy
• Woods, Lois
• Clarke, Christine
• Sternberg, Alex
• Owen, Tim
• Meakin, Sue
• Lake, Donna
• Culligan, Dominic
• Johannesson, Nicola
• Taylor, Gordon
• Tomlinson, Jill
• Shaw, Ann
• Ratcliffe, Maria
• Lamacchia, Mariella
• Duncan, Caroline
• Untiveros, Paraskevi
• Olaiya, Adetomilola
• Preston, Gavin
• Lawrie, Alastair
• Robertson, Charlotte
• Onyeakazi, Uzunma
• Radia, Rohini
• Stainthorp, Katherine
• Mc Connell, Steward
• Langton, Catherine
• Howcroft, Clare
• Saddiq, Ismail
• Byrne, Jennifer
• Lindsey‐Hill, Jo
• Badder, Denise
• Pol, Raj
• Bancroft, Rachel
• Springett, Sally
• Gray, Louisa
• Friesen, Heather
• Wardle, Katrin
• Murthy, Vidhya
• Kishore, Bhuvan
• Mayer, Georgina
• Nikolousis, Emmanouil
• Lovell, Richard
• Kartsios, Charalampos
• Lumley, Matthew
• Khawaja, Jahanzeb
• Murray, Duncan
• Milligan, Donald
• Dhani, Sundip
• Schumacher, Anne
• Enstone, Rosemarie
• Boal, Lauren
• Latter, Ruth
• Birt, Mark
• Watts, Emily
• Charlton, Andrew
• Forsyth, Hazel
• Lennard, Anne
• Robinson, Kate
• Grand, Effie
• Cullis, Jonathan
• Collins, Freya
• Tudgay, Saffron
• Salisbury, Sarah
• Mathew, Siju
• Tipler, Nicole
• Stobie, Emma
• Tribbeck, Michele
• Hebballi, Sangam
• Millar, Christopher
• Lala, Jai
• Chmeil, Jo
• Hufton, Lianne
• Dawson, Sarah
• Buyck, Hubertus
• Hayden, Jina
• Baluwala, Israel
• Wheeler, Matthew
• Miles, Rebecca
• Blakemore, Maureen
• Hargreaves, Ann
• Hayden, Gina
• Mo, Allison
• Uhe, Micheleine
• Indran, Tishya
• Wong, Jonathan
• Pearson, Sharon
• Parker, Jane
• Player, Matthew

Titel

Red cell transfusion in outpatients with myelodysplastic syndromes: a feasibility and exploratory randomised trial

Ist Teil von

• British journal of haematology, 2020-04, Vol.189 (2), p.279-290

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2020

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Summary Optimal red cell transfusion support in myelodysplastic syndromes (MDS) has not been tested and established. The aim of this study was to demonstrate feasibility of recruitment and follow‐up in an outpatient setting with an exploratory assessment of quality of life (QoL) outcomes (EORTC QLQ‐C30 and EQ‐5D‐5L). We randomised MDS patients to standardised transfusion algorithms comparing current restrictive transfusion thresholds (80 g/l, to maintain haemoglobin 85–100 g/l) with liberal thresholds (105 g/l, maintaining 110–125 g/l). The primary outcomes were measures of compliance to transfusion thresholds. Altogether 38 patients were randomised (n = 20 restrictive; n = 18 liberal) from 12 participating sites in UK, Australia and New Zealand. The compliance proportion for the intention‐to‐treat population was 86% (95% confidence interval 75–94%) and 99% (95–100%) for restrictive and liberal arms respectively. Mean pre‐transfusion haemoglobin concentrations for restrictive and liberal arms were 80 g/l (SD6) and 97 g/l (SD7). The total number of red cell units transfused on study was 82 in the restrictive and 192 in the liberal arm. In an exploratory analysis, the five main QoL domains were improved for participants in the liberal compared to restrictive arm. Our findings support the feasibility and need for a definitive trial to evaluate the effect of different red cell transfusion thresholds on patient‐centred outcomes.