Details

Autor(en) / Beteiligte

• Li, Xue
• Li, Wenbin
• Feng, Shilan
• Wang, Rong

Titel

Research progress on mechanism in adaptation of hemoglobin to plateau hypoxia

Ist Teil von

• Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2019-12, Vol.48 (6), p.674

Ort / Verlag

China

Erscheinungsjahr

2019

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Low oxygen partial pressure is the main cause of acute mountain sickness.Hemoglobin plays a crucial physiological role in the binding, utilization, transportation and release of oxygen in the body. To increase the capacity of oxygen binding of hemoglobin or the capacity of oxygen supply in tissues can help alleviate altitude sickness. However, increasing hemoglobin content has certain limitations. Using techniques from molecular biology, researchers are looking for endogenous or exogenous substances that can regulate the conformation of hemoglobin to increase oxygen uptake in the alveoli, or the availability of alveolar oxygen in the tissues. At present, the research on allosteric modulators to improve the affinity of hemoglobin has made some progress, and research on applying this mechanism to plateau hypoxia is also underway. This article reviews the relationship between hemoglobin and hypoxia, the structure of hemoglobin and the role of various allosteric modulators in hypoxia, which would provide informat