Details

Autor(en) / Beteiligte

• Uwamino, Yoshifumi
• Sakai, Akiko
• Nishimura, Tomoyasu
• Noguchi, Masayo
• Uno, Shunsuke
• Fujiwara, Hiroshi
• Mori, Masaaki
• Wakui, Masatoshi
• Murata, Mitsuru
• Hasegawa, Naoki

Titel

Effect of refrigeration of blood samples in lithium-heparin tubes on QuantiFERON TB Gold Plus test result

Ist Teil von

• Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020-03, Vol.26 (3), p.312-314

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The QuantiFERON TB Gold Plus (QFT-Plus) test is a newly approved interferon-gamma releasing assay test for detecting latent tuberculosis. Although blood samples for QFT test can be refrigerated for 48 h in lithium-heparin tubes according to package inserts, no published data are available on the effects of sample refrigeration on the test results. We conducted a clinical study that aimed to elucidate whether sample refrigeration for 48 h affects QFT-Plus test results. We collected 2 blood samples each from 40 participants for QFT-Plus; one sample was refrigerated before incubation for QFT-Plus assay, while the other sample was incubated soon after collection and treated as control. After comparing QFT-Plus test results of refrigerated samples and control samples, the concordance rate and kappa coefficient between them were 95% and 0.90, respectively. Thus, blood samples for QFT-Plus test can be refrigerated for 48 h in lithium-heparin tubes without influencing the test results.