Details

Autor(en) / Beteiligte

• Naifar, Manel
• Maalej Bouali, Manel
• Guidara, Wassim
• Ellouze, Ahmed Slim
• Jmal, Khalil
• Omri, Sana
• Messedi, Meriam
• Zouari, Lobna
• Elleuch, Aida
• Maalej, Mohamed
• Chaabouni, Khansa
• Charfi, Nada
• Turki, Mouna
• Jihène, Ben Thabet
• Ayadi, Fatma

Titel

Bipolar disorder vulnerability: The vitamin D path

Ist Teil von

• Canadian journal of psychiatry, 2020-03, Vol.65 (3), p.184-192

Ort / Verlag

United States

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Bipolar disorder (BD) etiopathogenesis is still not well elucidated. It has recently been proven that 25-hydroxy vitamin D (25OHD) has an anti-inflammatory and neuroprotective role. Our objectives were to measure 25OHD plasma levels in patients with BD in acute decompensation and compare them with patients with schizophrenia (SCZ) or schizoaffective disorder (SAD) and with healthy controls. This is a cross-sectional case-control study including male inpatients with a decompensation of their disease who were diagnosed with BD, SCZ or SAD according to DSM-5 criterias. The control group was constituted by unrelated healthy subjects, age-and-sex matched. The 25OHD level was significantly higher only in patients with BD compared to controls. 25OHD was also positively correlated to the PANSS scale (r = 0.282, p < 0.001) and to different MOCA scores (r = 0.326, p = 0.006) as well as aspects related to abstraction, attention and memory capacity. Multivariate analysis found that BD acute decompensation was independently related to the rise in plasma 25OHD (p = 0.012; OR =1.157, [1.032 -1.297]). Our study shows that BD acute decompensation is associated with the rise in plasma 25OHD synthesis. However, the vitamin D dosage relevance as a biomarker of this disease warrants a verification in other studies.