Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
By happy chance, the founding of Traffic in 1999 coincided with a clutch of reports that documented the endocytosis and recycling of classical cadherin adhesion receptors. This stimulated a concerted effort to elucidate the molecular regulation of cadherin endocytosis and to identify its functional implications. In particular, endocytosis provided new perspectives to understand how cadherins are modulated during tissue morphogenesis. In this short article, we consider some of what we have learnt about this problem and identify open questions for future research.
The endocytosis and recycling of classical cadherin adhesion receptors was discovered two decades ago. Since then we have learnt much about the cellular and molecular mechanisms that support and regulate cadherin trafficking. Here we consider their functional implications, focusing on tissue rearrangements during morphogenesis. We consider the progress that we have made and identify questions for the future, including the integration of cadherin traffic with cell signalling and the cytoskeleton.