Details

Autor(en) / Beteiligte

• Bernard-Valnet, Raphaël
• Berthet, Kimberly
• Bisseux, Maxime
• Broman, Brett
• Collaudin, Samuel
• Crunchant, Eléonore
• Dramé, Adèle
• Efthymiou, Stéphanie
• Entrevan, Marianne
• Grinand, Luc
• Kesisoglou, Eirini
• Mayer, Johannes
• Oliva, Anaïs
• Petkova, Denitsa
• Peyrégne, Stéphane
• Poinsot, Thomas
• Quintavalle, Annabelle
• Raguet, Louise
• Règue-Guyon, Mathilde
• Sinet, Flore
• Zablocki, Laurent
• Mahieux, Renaud
• Dutartre, Hélène
• Journo, Chloé

Titel

La réponse interféron de type I est-elle efficace pour contrôler l'infection par HTLV-1 ?

Ist Teil von

• Virologie (Montrouge, France), 2012-12, Vol.16 (6), p.356-370

Ort / Verlag

France

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Innate immunity plays a critical role in the host response to a viral infection. In particular, type I interferons (IFN-I) are major effectors of antiviral innate immunity. Herein, interplays between HTLV-1 and the IFN-I response are reviewed. Particular emphasis is put on virus sensing by innate immunity receptors and on anti-HTLV-1 effects of IFN-I. We also discuss HTLV-1-induced alteration of IFN-I function and how IFN-I/AZT treatment of adult T-cell leukemia/lymphoma patients can lead to complete remission despite virus-induced escape mechanisms.