Details

Autor(en) / Beteiligte

• Deane, Adam M
• Little, Lorraine
• Bellomo, Rinaldo
• Chapman, Marianne J
• Davies, Andrew R
• Ferrie, Suzie
• Horowitz, Michael
• Hurford, Sally
• Lange, Kylie
• Litton, Edward
• Mackle, Diane
• O'Connor, Stephanie
• Parker, Jane
• Peake, Sandra L
• Presneill, Jeffrey J
• Ridley, Emma J
• Singh, Vanessa
• van Haren, Frank
• Williams, Patricia
• Young, Paul
• Iwashyna, Theodore J

Titel

Outcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET). A Randomized Controlled Trial

Ist Teil von

• American journal of respiratory and critical care medicine, 2020-04, Vol.201 (7), p.814-822

Ort / Verlag

United States

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The long-term effects of delivering approximately 100% of recommended calorie intake via the enteral route during critical illness compared with a lesser amount of calories are unknown. Our hypotheses were that achieving approximately 100% of recommended calorie intake during critical illness would increase quality-of-life scores, return to work, and key life activities and reduce death and disability 6 months later. We conducted a multicenter, blinded, parallel group, randomized clinical trial, with 3,957 mechanically ventilated critically ill adults allocated to energy-dense (1.5 kcal/ml) or routine (1.0 kcal/ml) enteral nutrition. Participants assigned energy-dense nutrition received more calories (percent recommended energy intake, mean [SD]; energy-dense: 103% [28] vs. usual: 69% [18]). Mortality at Day 180 was similar (560/1,895 [29.6%] vs. 539/1,920 [28.1%]; relative risk 1.05 [95% confidence interval, 0.95-1.16]). At a median (interquartile range) of 185 (182-193) days after randomization, 2,492 survivors were surveyed and reported similar quality of life (EuroQol five dimensions five-level quality-of-life questionnaire visual analog scale, median [interquartile range]: 75 [60-85]; group difference: 0 [95% confidence interval, 0-0]). Similar numbers of participants returned to work with no difference in hours worked or effectiveness at work (  = 818). There was no observed difference in disability (  = 1,208) or participation in key life activities (  = 705). The delivery of approximately 100% compared with 70% of recommended calorie intake during critical illness does not improve quality of life or functional outcomes or increase the number of survivors 6 months later.