Details

Autor(en) / Beteiligte

• Zian, Wang
• Yang, Liu
• Peng, Wang
• Yifei, Jiang
• Min, Ji

Titel

Small molecular interaction-based fluorescence enhancement for second near-infrared imaging

Ist Teil von

• Nanomedicine (London, England), 2020-01, Vol.15 (2), p.115-129

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• This study described a new strategy to enhance second near-infrared (NIR-II) fluorescence intensity. NIR-II liposomes were prepared by thin film hydration method and their fluorescence properties were evaluated. The efficacy of the optimized liposome was then evaluated with low dose and irradiation. Indocyanine green-IR1061 liposome exhibited higher fluorescence intensity (∼fourfold than IR1061 liposome) with the red-shifted emission. The intensity of indocyanine green-IR1061 cationic liposome was enhanced to approximately tenfold, which allowed us to perform angiography with lower doses and less exposure time. We report a new and efficient way to enhance NIR-II fluorescence intensity. This could be used to acquire high temporal resolution and signal-to-background ratio fluorescence imaging.