Details

Autor(en) / Beteiligte

• Menzies-Gow, Andrew
• Bafadhel, Mona
• Busse, William W.
• Casale, Thomas B.
• Kocks, Janwillem W.H.
• Pavord, Ian D.
• Szefler, Stanley J.
• Woodruff, Prescott G.
• de Giorgio-Miller, Alexander
• Trudo, Frank
• Fageras, Malin
• Ambrose, Christopher S.

Titel

An expert consensus framework for asthma remission as a treatment goal

Ist Teil von

• Journal of allergy and clinical immunology, 2020-03, Vol.145 (3), p.757-765

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• With novel therapies in development, there is an opportunity to consider asthma remission as a treatment goal. In this Rostrum, we present a generalized framework for clinical and complete remission in asthma, on and off treatment, developed on the basis of medical literature and expert consensus. A modified Delphi survey approach was used to ascertain expert consensus on core components of asthma remission as a treatment target. Phase 1 identified other chronic inflammatory diseases with remission definitions. Phase 2 evaluated components of those definitions as well as published definitions of spontaneous asthma remission. Phase 3 evaluated a remission framework created using consensus findings. Clinical remission comprised 12 or more months with (1) absence of significant symptoms by validated instrument, (2) lung function optimization/stabilization, (3) patient/provider agreement regarding remission, and (4) no use of systemic corticosteroids. Complete remission was defined as clinical remission plus objective resolution of asthma-related inflammation and, if appropriate, negative bronchial hyperresponsiveness. Remission off treatment required no asthma treatment for 12 or more months. The proposed framework is a first step toward developing asthma remission as a treatment target and should be refined through future research, patient input, and clinical study.