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Hierarchical Self‐Assembly of Poly‐Pseudorotaxanes into Artificial Microtubules
Ist Teil von
Angewandte Chemie International Edition, 2020-02, Vol.59 (9), p.3460-3464
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2020
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Hierarchical self‐assembly of building blocks over multiple length scales is ubiquitous in living organisms. Microtubules are one of the principal cellular components formed by hierarchical self‐assembly of nanometer‐sized tubulin heterodimers into protofilaments, which then associate to form micron‐length‐scale, multi‐stranded tubes. This peculiar biological process is now mimicked with a fully synthetic molecule, which forms a 1:1 host‐guest complex with cucurbit[7]uril as a globular building block, and then polymerizes into linear poly‐pseudorotaxanes that associate laterally with each other in a self‐shape‐complementary manner to form a tubular structure with a length over tens of micrometers. Molecular dynamic simulations suggest that the tubular assembly consists of eight poly‐pseudorotaxanes that wind together to form a 4.5 nm wide multi‐stranded tubule.
Taking shape: Cucurbit[7]uril‐threaded pseudorotaxanes containing two thiol groups at both termini polymerize by reversible disulfide bond formation into protofilament‐like linear poly‐pseudorotaxanes. These poly‐pseudorotaxanes associate laterally with each other in a self‐shape‐complementary manner to form multi‐stranded artificial microtubules.