Details

Autor(en) / Beteiligte

• Yao, H H
• Wang, Y N
• Zhang, X
• Zhao, J X
• Jia, Y
• Wang, Z
• Li, Z G

Titel

Clinical characteristics and treatment outcomes of macrophage activation syndrome in adults: A case series of 67 patients

Ist Teil von

• Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2019-12, Vol.51 (6), p.996-1002

Ort / Verlag

China

Erscheinungsjahr

2019

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To described the clinical and laboratory features and outcome of 67 macrophage activation syndrome (MAS). A total of 67 MAS patients from three centers from January 2007 to December 2017 were enrolled. Clinical and laboratory features, and response to therapy were analyzed. Predictive factors for remission and survival were explored. We identified a mean age of (36.1±16.3) years at diagnosis of MAS and a median connective tissue disease (CTD) duration of 8 months prior to MAS development. Among 67 MAS patients identified, underlying diseases included adult-onset Still's disease (AOSD) in 56.7% and systemic lupus erythematosus (SLE) in 30.0%. Fever and splenomegaly were found in 100.0% and 82.1% of the patients, respectively. Ferritinemia and elevation of serum soluble interleukin-2 receptor was seen in 100.0% and 93.2% of the patients. Serum levels of alanine aminotransferase, D-dimer, ferritin and C reactive protein were significantly higher in MAS associated with the AOSD patients than in MAS associated wit