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Costa-Paschoalini et al discuss a case of oral desensitization to sesame. The protocol was approved by the Medical Research Ethics Committee of the University of Campinas, Campinas, Brazil. The patient was a 48-year-old white woman who reported anaphylaxis or skin-restricted reactions beginning at age 27 years following the consumption of sesame-rich foods and even after the consumption of trace amounts of the antigen. She required repeated administration of epinephrine for recurrent episodes of anaphylaxis.