Details

Autor(en) / Beteiligte

• Pellegrini, Marianna
• Cioffi, Iolanda
• Evangelista, Andrea
• Ponzo, Valentina
• Goitre, Ilaria
• Ciccone, Giovannino
• Ghigo, Ezio
• Bo, Simona

Titel

Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis

Ist Teil von

• Reviews in endocrine & metabolic disorders, 2020-03, Vol.21 (1), p.17-33

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Restriction in meal timing has emerged as a promising dietary approach for the management of obesity and dysmetabolic diseases. The present systematic review and meta-analysis summarized the most recent evidence on the effect of time-restricted feeding (TRF) on weight-loss and cardiometabolic variables in comparison with unrestricted-time regimens. Studies involving TRF regimen were systematically searched up to January 2019. Effect size was expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). A total of 11 studies, 5 randomized controlled trials and 6 observational, were included. All selected studies had a control group without time restriction; hours of fasting ranged from 12-h until 20-h and study duration from 4 to 8-weeks. Most studies involved the Ramadan fasting. TRF determined a greater weight-loss than control regimens (11 studies, n  = 485 subjects) (WMD: −1.07 kg, 95%CI: −1.74 to −0.40; p  = 0.002; I 2  = 56.2%), unrelated to study design. The subgroup analysis showed an inverse association between TRF and fat free mass in observational studies (WMD: −1.33 kg, 95%CI: −2.55 to −0.11; p  = 0.03; I 2  = 0%). An overall significant reduction in fasting glucose concentrations was observed with TRF regimens (7 studies, n =  363 subjects) (WMD: −1.71 mg/dL, 95%CI: −3.20 to −0.21; p  = 0.03; I 2  = 0%), above all in trials (WMD:-2.45 mg/dL, 95%CI: −4.72 to −0.17; p = 0.03; I 2  = 0%). No between-group differences in the other variables were found. TRF regimens achieved a superior effect in promoting weight-loss and reducing fasting glucose compared to approaches with unrestricted time in meal consumption. However, long-term and well-designed trials are needed to draw definitive conclusions.