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Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis
Ist Teil von
American journal of otolaryngology, 2020-03, Vol.41 (2), p.102321-102321, Article 102321
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2020
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale.
The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test.
The ARRP showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells (p < .05) than the JRRP samples. The presence of CD15+ cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01).
There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity.
•There is difference between inflammatory cell population in juvenile and adult recurrent respiratory pappilomatosis.•Adults showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells than the juvenile patients.•MUM-1+ cells were correlated with lower Derkay index.