Details

Autor(en) / Beteiligte

• Viet Cuong, Le Canh
• Anh, Le Tuan
• Huu Dat, Ton That
• Anh, Tran Thi Phuong
• Lien, Le Quynh
• Kim, Young Ho
• Tuan Anh, Hoang Le

Titel

Cytotoxic and anti-inflammatory activities of secondary metabolites from Ophiorrhiza baviensis growing in Thua Thien Hue, Vietnam

Ist Teil von

• Natural product research, 2021-11, Vol.35 (22), p.4218-4224

Ort / Verlag

Taylor & Francis

Erscheinungsjahr

2021

Quelle

Taylor & Francis 数据库

Beschreibungen/Notizen

• A new ursane-type triterpene, 3β,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2-9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2-5 were found for the first time from the genus Ophiorrhiza, while compounds 6-9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR ( 1 H-NMR, 13 C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.