Details

Autor(en) / Beteiligte

• Watanabe, Masao
• Nakamoto, Yuji
• Ishimori, Takayoshi
• Saga, Tsuneo
• Kido, Aki
• Hamanishi, Junzo
• Hamanaka, Yasuyo
• Togashi, Kaori

Titel

Prognostic utility of FDG PET/CT in advanced ovarian, fallopian and primary peritoneal high-grade serous cancer patients before and after neoadjuvant chemotherapy

Ist Teil von

• Annals of nuclear medicine, 2020-02, Vol.34 (2), p.128-135

Ort / Verlag

Singapore: Springer Singapore

Erscheinungsjahr

2020

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Objectives In patients with advanced ovarian, fallopian and primary peritoneal carcinoma, complete interval debulking surgery (IDS) is often performed after neoadjuvant chemotherapy (NAC) to achieve long progression-free survival (PFS) and overall survival (OS). We aimed to investigate the utility of 2-deoxy-2-[F-18]fluoro- d -glucose (FDG) PET/CT in patients with these malignancies who underwent complete IDS. Methods Between 2009 and 2017, twenty-two patients underwent FDG PET/CT scans before and after NAC. The highest SUVmax/peak (standardized uptake value), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) for whole lesions were defined as target SUVmax/peak, tMTV and tTLG, respectively. We also calculated these reduction rates during NAC. These parameters were compared between the groups with platinum-free interval (PFI) > 12 months ( n  = 10) and those with PFI ≤ 12 months ( n  = 12). The PFS and OS were evaluated using these quantitative parameters, and in terms of the presence of visually detectable residual lesions after NAC. Results The target SUVmax/peak before NAC, the reduction rates in the target SUVmax, tMTV and tTLG were significantly higher in the group with PFI > 12 months than the shorter PFI group ( p  < 0.05). Especially in PFS, the higher reduction rates in the target SUVmax/peak, tMTV, and tTLG had an excellent prognostic stratification ( p  < 0.05) and the FDG visually negative group after NAC had a significantly better prognosis than the other group ( p  < 0.01). Conclusions The reduction rate of FDG PET-based quantitative values and visual analysis after NAC demonstrated prognostic potential, especially in PFS.