Details

Autor(en) / Beteiligte

• Lee, Hyune‐Jea
• Roberts, Robert C.
• Im, Do Jin
• Yim, Se‐Jun
• Kim, Heejin
• Kim, Ji Tae
• Kim, Dong‐Pyo

Titel

Enhanced Controllability of Fries Rearrangements Using High‐Resolution 3D‐Printed Metal Microreactor with Circular Channel

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2019-12, Vol.15 (50), p.e1905005-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• High‐resolution 3D‐printed stainless steel metal microreactors (3D‐PMRs) with different cross‐sectional geometry are fabricated to control ultrafast intramolecular rearrangement reactions in a comparative manner. The 3D‐PMR with circular channel demonstrates the improved controllability in rapid Fries‐type rearrangement reactions, because of the superior mixing efficiency to rectangular cross‐section channels (250 µm × 125 µm) which is confirmed based on the computational flow dynamics simulation. Even in case of very rapid intramolecular rearrangement of sterically small acetyl group occurring in 333 µs of reaction time, the desired intermolecular reaction can outpace to the undesired intramolecular rearrangement using 3D‐PMR to result in high conversion and yield. Three types of high‐resolution 3D‐printed stainless steel metal microreactors (3D‐PMRs) with programmed mixing efficiencies are fabricated by a high‐resolution selective laser melting method to control ultrafast reactions in a comparative manner. The 3D‐PMR with circular channel demonstrates the selectively controlled performance in the ultrafast anionic Fries rearrangement reactions even in the case of very rapid intramolecular rearrangement of the sterically small acetyl group.