Biological trace element research, 2020-07, Vol.196 (1), p.74-85
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Role of Magnesium in Type 2 Diabetes Mellitus
- Ist Teil von
- Biological trace element research, 2020-07, Vol.196 (1), p.74-85
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Magnesium (in its ionized and biologically active form, Mg 2+ ) is an essential trace element that participates in numerous physiologic processes. Abnormal Mg 2+ homeostasis can lead to many metabolic disorders, including diabetes mellitus (DM) and its complications. Mg 2+ participates in energy generation and is required for DNA and RNA synthesis, reproduction, and protein synthesis. Additionally, Mg 2+ acts as a calcium antagonist and protects vascular endothelial cells from oxidative stress. Imbalances in Mg 2+ status, more frequently hypomagnesemia, inhibit glucose transporter type 4 translocation, increase insulin resistance, affect lipid metabolism, induce oxidative stress, and impair the antioxidant system of endothelial cells, In these ways, hypomagnesemia contributes to the initiation and progression of DM and its macrovascular and microvascular complications. In this review, we summarize recent advances in knowledge of the mechanisms whereby Mg 2+ regulates insulin secretion and sensitivity. In addition, we discuss the future prospects for research regarding the mechanisms whereby Mg 2+ status impacts DM and its complications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-4984eISSN: 1559-0720DOI: 10.1007/s12011-019-01922-0Titel-ID: cdi_proquest_miscellaneous_2314009730
- Format
- –
- Schlagworte
- Antioxidants, Biochemistry, Biological activity, Biomedical and Life Sciences, Biotechnology, Calcium, Calcium - metabolism, Calcium antagonists, Deoxyribonucleic acid, Diabetes, Diabetes mellitus, Diabetes mellitus (non-insulin dependent), Diabetes Mellitus, Type 2 - metabolism, DNA, DNA biosynthesis, Endothelial cells, Endothelial Cells - drug effects, Endothelial Cells - metabolism, Glucose transporter, Homeostasis, Humans, Hypomagnesemia, Insulin, Insulin - metabolism, Insulin resistance, Insulin secretion, Life Sciences, Lipid metabolism, Lipids, Magnesium, Magnesium - metabolism, Magnesium - pharmacology, Metabolic disorders, Microvasculature, Nucleic acids, Nutrition, Oncology, Oxidation resistance, Oxidative metabolism, Oxidative stress, Oxidative Stress - drug effects, Protein biosynthesis, Protein synthesis, RNA, Secretion, Trace elements, Transcription, Translocation