Details

Autor(en) / Beteiligte

• Siciliano, Rosa Anna
• Mazzeo, Maria Fiorella
• Ferretta, Anna
• Pacelli, Consiglia
• Rosato, Antonio
• Papa, Francesco
• Scacco, Salvatore
• Papa, Sergio
• Cocco, Tiziana
• Lippolis, Rosa

Titel

Decreased amount of vimentin N-terminal truncated proteolytic products in parkin-mutant skin fibroblasts

Ist Teil von

• Biochemical and biophysical research communications, 2020-01, Vol.521 (3), p.693-698

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Vimentin, a member of cytoskeleton intermediate filaments proteins, plays a critical role in cell structure and dynamics. The present proteomic study reveals reduced amount of six different lengths, N-terminal truncated proteolytic products of vimentin, in the primary skin fibroblasts from two unrelated PD patients, as compared to control fibroblasts. The decreased amount of N-terminal truncated forms of vimentin in parkin-mutant fibroblasts, could contribute to impairment of cellular function, potentially contributing to the pathogenesis of Parkinson disease. •Reduced amount of six N-truncated VIM forms in parkin-mutant fibroblasts.•Decreased VIM truncated forms, could be due to Ca2+-proteinases activation.•VIM cleavage, impairing various VIM functions, could play a role in PD pathogenesis.