Details

Autor(en) / Beteiligte

• Kirby, Miranda
• Tanabe, Naoya
• Vasilescu, Dragoş M
• Cooper, Joel D
• McDonough, John E
• Verleden, Stijn E
• Vanaudenaerde, Bart M
• Sin, Don D
• Tan, Wan C
• Coxson, Harvey O
• Hogg, James C

Titel

Computed Tomography Total Airway Count Is Associated with the Number of Micro-Computed Tomography Terminal Bronchioles

Ist Teil von

• American journal of respiratory and critical care medicine, 2020-03, Vol.201 (5), p.613-615

Ort / Verlag

United States: American Thoracic Society

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Previous reports based on micro-computed tomography (CT) imaging have shown that the number of terminal bronchioles (TBs) is reduced by 40% in individuals with mild or moderate chronic obstructive pulmonary disease (COPD) and by 90% in those with very severe COPD. A study using multidetector CT (MDCT) showed that the number of visualized and quantified central airways--referred to as the total airway count (TAC)--is significantly reduced by 19% in individuals with mild or moderate COPD and associated with longitudinal lung function decline. Taken together, these findings suggest that the pathological process responsible for TB reduction/remodeling may extend into the larger airways that can be detected by MDCT. Here, a study is presented that aims to determine whether there is an association between MDCT TAC and estimates of the number of TBs obtained by micro-CT in the same lungs.