Details

Autor(en) / Beteiligte

• Pebody, Richard G.
• Whitaker, Heather
• Ellis, Joanna
• Andrews, Nick
• Marques, Diogo F.P.
• Cottrell, Simon
• Reynolds, Arlene J.
• Gunson, Rory
• Thompson, Catherine
• Galiano, Monica
• Lackenby, Angie
• Robertson, Chris
• O'Doherty, Mark G.
• Owens, Katie
• Yonova, Ivelina
• Shepherd, Samantha J.
• Moore, Catherine
• Johnston, Jillian
• Donati, Matthew
• McMenamin, Jim
• Lusignan, Simon de
• Zambon, Maria

Titel

End of season influenza vaccine effectiveness in primary care in adults and children in the United Kingdom in 2018/19

Ist Teil von

• Vaccine, 2020-01, Vol.38 (3), p.489-497

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• 2018/19 was the first season of introduction of a newly licensed adjuvanted influenza vaccine (aTIV) for adults aged 65 years and over and the sixth season in the roll-out of a childhood influenza vaccination programme with a quadrivalent live attenuated influenza vaccine (LAIV). The season saw mainly A(H1N1)pdm09 and latterly A(H3N2) circulation. End-of-season adjusted vaccine effectiveness (aVE) estimates against laboratory confirmed influenza infection in primary care were calculated using the test negative case control method adjusting for key confounders. End-of-season aVE was 44.3% (95% CI: 26.8, 57.7) against all laboratory-confirmed influenza; 45.7% (95% CI: 26.0, 60.1) against influenza A(H1N1)pdm09 and 35.1% (95% CI: −3.7,59.3) against A(H3N2). Overall aVE was 49.9% (95%CI: −13.7, 77.9) for all those ≥ 65 years of age and 62.0% (95% CI: 3.4, 85.0) for those who received aTIV. Overall aVE for 2–17 year olds receiving LAIV was 48.6% (95% CI: −4.4, 74.7). The paper provides evidence of overall significant influenza VE in 2018/19, most notably against influenza A(H1N1)pdm09, however, as seen in 2017/18, there was reduced, non-significant VE against A(H3N2). aTIV provided significant protection for those 65 years of age and over.