Science China. Life sciences, 2019-11, Vol.62 (11), p.1420-1458
2019
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- Autor(en) / Beteiligte
- Titel
- Regulation of glucose and lipid metabolism in health and disease
- Ist Teil von
- Science China. Life sciences, 2019-11, Vol.62 (11), p.1420-1458
- Ort / Verlag
- Beijing: Science China Press
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals, is a key component of cell membranes although it does not generate ATP. The metabolisms of glucose, fatty acids and cholesterol are often intertwined and regulated. For example, glucose can be converted to fatty acids and cholesterol through de novo lipid biosynthesis pathways. Excessive lipids are secreted in lipoproteins or stored in lipid droplets. The metabolites of glucose and lipids are dynamically transported intercellularly and intracellularly, and then converted to other molecules in specific compartments. The disorders of glucose and lipid metabolism result in severe diseases including cardiovascular disease, diabetes and fatty liver. This review summarizes the major metabolic aspects of glucose and lipid, and their regulations in the context of physiology and diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1674-7305eISSN: 1869-1889DOI: 10.1007/s11427-019-1563-3Titel-ID: cdi_proquest_miscellaneous_2312273397
- Format
- –
- Schlagworte
- Animals, Biological Transport, Biomedical and Life Sciences, Cardiovascular diseases, Cell membranes, Cholesterol, Cholesterol - metabolism, Diabetes mellitus, Diabetes Mellitus, Type 2 - genetics, Diabetes Mellitus, Type 2 - pathology, Fatty acids, Fatty Acids - metabolism, Fatty liver, Glucose - metabolism, Humans, Insulin Resistance - genetics, Insulin Resistance - physiology, Life Sciences, Lipid metabolism, Lipid Metabolism - physiology, Lipids, Lipoproteins, Lipoproteins - metabolism, Liver - metabolism, Liver diseases, Membrane Transport Proteins - genetics, Membrane Transport Proteins - metabolism, Metabolism, Metabolites, Non-alcoholic Fatty Liver Disease - genetics, Non-alcoholic Fatty Liver Disease - pathology, Obesity - genetics, Obesity - pathology, Review